The last proposed mechanism of RBC vasodilation during the existence of nitrite would be the reduction of nitrite to NO by Hb. Brooks initially studied the nitrite Hb interaction in 1937 which work was later extended by Doyle in 1981 (Brooks, 1937; Doyle et al., 1981). Nitrite reacts with deoxygenated Hb to variety metHb and NO (Brooks, 1937; Doyle